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Nutrition affects cognition and mental health as the brain structure and function are dependent on nutritional inputs [].These dietary factors affect multiple brain processes involving neurotransmitter pathways, synaptic transmission, membrane fluidity and signal transduction pathways that are associated with synaptic plasticity [].During this period, the intake of n-3 and n-6 long chain polyunsaturated fatty acids (LCPUFAs), particularly docosahexanoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (AA), have been proven to be beneficial for the development of sensory, cognitive and neuromotor systems in human and animal [].An optimal supply of antioxidants such as vitamin E is thought to be beneficial to the cognitive development in infants.Learning and behavioural experiments were conducted only in male off-spring rats using the Morris water maze.Results showed that prenatal and postnatal TRF supplementation increased the brain (4–6 fold increase) and plasma α-tocotrienol (0.8 fold increase) levels in male off-springs.Currently tocotrienols are gaining much attention due to their potent antioxidant and neuroprotective properties.It is thus compelling to look at the effects of prenatal and early postnatal tocotrienols supplementation, on cognition and behavioural development among offsprings of individual supplemented with tocotrienols.

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Various factors such as nutrition, environment and genetics have strong influence on memory and learning.α-Tocotrienol and α-tocopherol were the major vitamin E fraction found in plasma followed by γ- and δ-tocotrienol.However, the tocotrienol levels were very much lower than the tocopherol levels in plasma.The levels of α-, γ-and δ-tocotrienol were found to have increased among the TRF and DTRF supplemented animals compared to the control animals.It was also noted that the level of β-tocotrienol fraction was negligible and was no different among the TRF and DTRF supplemented rats.

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